Melasma is a chronic skin condition that causes discoloration on the face. It usually appears as brown, tan, or blue-gray patches along the upper cheeks, upper lip, forehead, and chin. Sometimes appear as dark irregular skin patches. It is unsafe to remove all pigmentation which can lead to irreversible damage. Melasma and hyperpigmentation can be very distressing for sufferers so it is important to treat the condition in a safe and effective way.
While hydroquinone and AHAs will lighten the pigmentation, prolonged use of these chemical ingredients will create an unnatural looking mask effect that is totally irreversible.
The results are often worse than the condition itself. It is important to properly diagnose hyperpigmentation using a Wood’s lamp (wavelength 340-400 nanometres). Epidermal pigment is enhanced during examination with a Wood’s lamp, whereas dermal pigment is not.
Dermal pigment is very difficult to treat; however, 70 per cent of the population has hyperpigmentation spots on the epidermis.
The primary factors causing melasma are hormonal changes and external sun exposure, so the most effective and long-lasting treatments are aimed at these causes.
Dr Georghy will give you a physical exam and ask about your medical and family history. He may also perform tests, such as: Blood test, hormonal study, light microscopy.
The treatment and the result vary from patient to patient.
Treatments for melasma may include: IPL, IPH, LED, Polarized Light and Infrared Heat, Medical Laser, WISHPro and Natural supplements.
Vitamin C and Glutathione IOV therapy can be helpful. Glutathione is an ubiquitous compound found in our bodies. Aside from its many ascribed biologic functions, it has also been implicated in skin lightening. We review in vitro and in vivo studies that show evidence of its involvement in the melanogenic pathway and shed light on the its anti-melanogenic effect.
Mechanism of action:
- Direct inactivation of the enzyme tyrosinese by binding with the copper-containing active site of the enzyme;
- Mediating the switch mechanism from eumelanin to phaeomelanin production;
- Quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin formation; and
- Modulation of depigmenting abilities of melano-cytotoxic agents.
- These concepts supported by the various experimental evidence presented form basis for future research in the use of glutathione in the treatment of pigmentary disorders
MELANOGENESIS and MELANOCYTE
Consumer warning - North Shore Cosmetic: Medical and Dental, use 'before and after' photos to showcase possible outcomes and empower patients to make informed decisions. They are not intended to be misleading or deceptive. We have made an effort to ensure that all photographs are taken under the same light, with the same camera, with the same exposure and positioning. No photo has been re-touched or altered in anyway. All Photos are Copyright Dr Joseph Georghy, 2017.
Consumers must be aware that all Cosmetic results can vary from person to person. Please view with caution.
‘Any surgical or invasive procedure carries risks. Before proceeding, you should seek a second opinion from an appropriately qualified health practitioner.’
Case Study 1
Before and After
Case Study 2
Before and After
Case Study 3
The results are permanent (4.5 years follow up)
Before and After
Case Study 4
The result after 15 year follow up
Before and After (right)
Before and After (left)
Skin Hydrating and Whitening effects of Vitamin C and Glutathione in Asian skin types
BY KEITH ONG / POSTED IN ANTI-AGEING, DERMATOLOGY ON OCTOBER 14, 2015
Keith Ong describes the results from his study on the effects of multiple intravenous injections of vitamin C and glutathione;
Most patients (n=270, 95.4%) perceived a certain degree of skin hydration and whitening after six Vit C and GSH intravenous injections and most patients (mean score 4.99 out of 7) were satisfied with the results, without experiencing any serious adverse event.
More studies could be conducted to evaluate the efficacy of intravenous Vit C and GSH injections, especially on the areas of skin whitening, post-operation wound healing, repair of second and third degree burns, and repair of photo-aged skin.
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